Biology:TFAP4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.[1]
Function
Transcription factor AP4 is a member of the basic helix-loop-helix (bHLH) transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.
References
Further reading
- Hu YF; Lüscher B; Admon A et al. (1991). "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity". Genes Dev. 4 (10): 1741–52. doi:10.1101/gad.4.10.1741. PMID 2123466.
- "Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro". Nature 332 (6164): 557–61. 1988. doi:10.1038/332557a0. PMID 2833704. Bibcode: 1988Natur.332..557M.
- "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188–99. 1994. doi:10.1128/JVI.68.11.7188-7199.1994. PMID 7933101.
- Lewis TB; Wood S; Michaelis EK et al. (1996). "Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24". Genomics 32 (1): 131–3. doi:10.1006/geno.1996.0088. PMID 8786101.
- "Structure and regulation of the human growth hormone-releasing hormone receptor gene". Mol. Endocrinol. 12 (2): 233–47. 1998. doi:10.1210/mend.12.2.0057. PMID 9482665.
- "The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4". J. Mol. Biol. 291 (1): 71–82. 1999. doi:10.1006/jmbi.1999.2963. PMID 10438607.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Beausoleil SA; Jedrychowski M; Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Martin J; Han C; Gordon LA et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553. Bibcode: 2004Natur.432..988M. https://digital.library.unt.edu/ark:/67531/metadc788092/m2/1/high_res_d/842679.pdf.
- Olsen JV; Blagoev B; Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
External links
- TFAP4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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