Biology:E2F3
 Generic protein structure example |
Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.[1]
Function
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.[2]
Interactions
E2F3 has been shown to interact with TFE3[3] and RYBP.[4]
See also
References
- ↑ "The retinoblastoma protein binds to a family of E2F transcription factors". Molecular and Cellular Biology 13 (12): 7813–25. Dec 1993. doi:10.1128/mcb.13.12.7813. PMID 8246996.
- ↑ "Entrez Gene: E2F3 E2F transcription factor 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1871.
- ↑ "Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor". Molecular and Cellular Biology 23 (11): 3707–20. Jun 2003. doi:10.1128/MCB.23.11.3707-3720.2003. PMID 12748276.
- ↑ "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal 21 (21): 5775–86. Nov 2002. doi:10.1093/emboj/cdf577. PMID 12411495.
Further reading
- "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 1 (5): 223–9. 1995. doi:10.1093/dnares/1.5.223. PMID 7584044.
- "In vivo association of E2F and DP family proteins". Molecular and Cellular Biology 15 (5): 2536–46. May 1995. doi:10.1128/mcb.15.5.2536. PMID 7739537.
- "Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F". Molecular and Cellular Biology 16 (4): 1659–67. Apr 1996. doi:10.1128/mcb.16.4.1659. PMID 8657141.
- "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proceedings of the National Academy of Sciences of the United States of America 93 (15): 7594–9. Jul 1996. doi:10.1073/pnas.93.15.7594. PMID 8755520. Bibcode: 1996PNAS...93.7594R.
- "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members". Journal of Cell Science 109 (7): 1717–26. Jul 1996. doi:10.1242/jcs.109.7.1717. PMID 8832394.
- "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit". Genes & Development 10 (7): 851–61. Apr 1996. doi:10.1101/gad.10.7.851. PMID 8846921.
- "The subcellular localization of E2F-4 is cell-cycle dependent". Proceedings of the National Academy of Sciences of the United States of America 94 (10): 5095–100. May 1997. doi:10.1073/pnas.94.10.5095. PMID 9144196. Bibcode: 1997PNAS...94.5095L.
- "Specific regulation of E2F family members by cyclin-dependent kinases". Molecular and Cellular Biology 17 (7): 3867–75. Jul 1997. doi:10.1128/mcb.17.7.3867. PMID 9199321.
- "Differential activities of E2F family members: unique functions in regulating transcription". Molecular Carcinogenesis 22 (3): 190–8. Jul 1998. doi:10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P. PMID 9688145.
- "E2f3 is critical for normal cellular proliferation". Genes & Development 14 (6): 690–703. Mar 2000. doi:10.1101/gad.14.6.690. PMID 10733529.
- "Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression". Genes & Development 14 (7): 804–16. Apr 2000. doi:10.1101/gad.14.7.804. PMID 10766737.
- "Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins". Molecular and Cellular Biology 20 (10): 3626–32. May 2000. doi:10.1128/MCB.20.10.3626-3632.2000. PMID 10779352.
- "Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region". Oncogene 19 (30): 3422–33. Jul 2000. doi:10.1038/sj.onc.1203682. PMID 10918599.
- "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". European Journal of Biochemistry 268 (23): 6076–82. Dec 2001. doi:10.1046/j.0014-2956.2001.02555.x. PMID 11733001.
- "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes & Development 16 (2): 235–44. Jan 2002. doi:10.1101/gad.943102. PMID 11799066.
- "E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints". Genes & Development 16 (2): 245–56. Jan 2002. doi:10.1101/gad.949802. PMID 11799067.
- "E2F-3B is a physiological target of cyclin A". The Journal of Biological Chemistry 277 (26): 23493–9. Jun 2002. doi:10.1074/jbc.M202629200. PMID 11980909.
- "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal 21 (21): 5775–86. Nov 2002. doi:10.1093/emboj/cdf577. PMID 12411495.
External links
- E2F3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
