Biology:Interleukin 1 receptor, type II
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.
Function
The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. IL-1R2 protein also interacts non-productively with the second component of the signaling IL-1 receptor, namely IL-1RAcP,[1] and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography.[2] Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.[3]
See also
References
- ↑ Lang, D; Knop, J; Wesche, H; Raffetseder, U; Kurrie, R; Boraschi, D; Martin, MU (1998). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.". Journal of Immunology 161 (12): 6871–6877. doi:10.4049/jimmunol.161.12.6871. PMID 9862719.
- ↑ Wang, Dongli; Zhang, Senyan; Li, Liang; Liu, Xi; Mei, Kunrong; Wang, Xinquan (29 August 2010). "Structural insights into the assembly and activation of IL-1β with its receptors". Nature Immunology 11 (10): 905–911. doi:10.1038/ni.1925. PMID 20802483.
- ↑ "Entrez Gene: IL1R2 interleukin 1 receptor, type II". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7850.
Further reading
- "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". The EMBO Journal 10 (10): 2821–32. Oct 1991. doi:10.1002/j.1460-2075.1991.tb07831.x. PMID 1833184.
- "Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils". The Journal of Biological Chemistry 266 (30): 20311–5. Oct 1991. doi:10.1016/S0021-9258(18)54924-3. PMID 1834644.
- "Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome". The Journal of Clinical Investigation 88 (5): 1452–9. Nov 1991. doi:10.1172/JCI115454. PMID 1834697.
- "Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor". Laboratory Investigation 73 (3): 347–55. Sep 1995. PMID 7564267.
- "Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist". Proceedings of the National Academy of Sciences of the United States of America 92 (5): 1714–8. Feb 1995. doi:10.1073/pnas.92.5.1714. PMID 7878046. Bibcode: 1995PNAS...92.1714S.
- "Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids". Journal of Immunology 153 (10): 4766–74. Nov 1994. doi:10.4049/jimmunol.153.10.4766. PMID 7963543.
- "Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses". Journal of Immunology 153 (12): 5802–9. Dec 1994. doi:10.4049/jimmunol.153.12.5802. PMID 7989776.
- "The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor". The Journal of Experimental Medicine 179 (2): 739–43. Feb 1994. doi:10.1084/jem.179.2.739. PMID 8294881.
- "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science 261 (5120): 472–5. Jul 1993. doi:10.1126/science.8332913. PMID 8332913. Bibcode: 1993Sci...261..472C.
- "Reactive oxygen intermediates cause rapid release of the interleukin-1 decoy receptor from human myelomonocytic cells". Blood 87 (5): 1682–6. Mar 1996. doi:10.1182/blood.V87.5.1682.bloodjournal8751682. PMID 8634411.
- "Flow cytometric analysis of cytokine receptors on human Langerhans' cells. Changes observed after short-term culture". Immunology 87 (2): 317–25. Feb 1996. doi:10.1046/j.1365-2567.1996.451513.x. PMID 8698397.
- "Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA". The Journal of Biological Chemistry 271 (34): 20965–72. Aug 1996. doi:10.1074/jbc.271.34.20965. PMID 8702856.
- "Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes". Journal of Immunology 156 (7): 2534–41. Apr 1996. doi:10.4049/jimmunol.156.7.2534. PMID 8786316.
- "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine 8 (8): 636–41. Aug 1996. doi:10.1006/cyto.1996.0085. PMID 8894439.
- "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". Journal of Neuroimmunology 70 (2): 113–22. Nov 1996. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719.
- "Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13". The Journal of Infectious Diseases 175 (1): 118–22. Jan 1997. doi:10.1093/infdis/175.1.118. PMID 8985204.
- "Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation". Proceedings of the National Academy of Sciences of the United States of America 94 (11): 5814–9. May 1997. doi:10.1073/pnas.94.11.5814. PMID 9159157. Bibcode: 1997PNAS...94.5814R.
- "Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes". Biology of Reproduction 56 (6): 1513–26. Jun 1997. doi:10.1095/biolreprod56.6.1513. PMID 9166705.
- "Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome". Journal of Clinical Immunology 17 (3): 253–61. May 1997. doi:10.1023/A:1027314713231. PMID 9168406.
- "Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis". Cytokine 9 (12): 1023–7. Dec 1997. doi:10.1006/cyto.1997.0260. PMID 9417814.
External links
- IL1R2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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