View source for Medicine:Panoramic radiograph

{{Short description|Type of X-ray}}
{{Infobox diagnostic |
  Name        = Panoramic radiograph |
  Image       = Panoramicfilm.JPG | 
  Caption     = A dental panoramic radiograph, showing the [[Biology:Maxilla|maxilla]] and mandible, all the teeth including the "wisdom teeth," the frontal and [[Biology:Maxilla|maxilla]]ry [[Biology:Sinus (anatomy)|sinus]]es, the nasal cavity and the temporomandibular [[Biology:Joint|joint]] and other near by head and neck anatomy. |
  ICD10       = |
  ICD9        = |
  MeshID      = D011862 |
  OPS301      = |
  OtherCodes  = |
  HCPCSlevel2 = 
}}
[[File:Mixed dentition pan.jpg|thumb|A panoramic radiograph of a 9 year old in mixed dentition]]
[[File:Basic panoramic radiograph.jpg|thumb|A basic panoramic radiograph]]
[[Image:Panoramic Xray.jpg|thumb|A Panoramic radiography machine.]]

A '''panoramic radiograph''' is a panoramic scanning dental X-ray of the upper and lower [[Medicine:Jaw|jaw]]. It shows a two-dimensional view of a half-circle from [[Medicine:Ear|ear]] to ear. Panoramic radiography is a form of [[Physics:Focal plane tomography|focal plane tomography]]; thus, images of multiple [[Plane (geometry)|planes]] are taken to make up the composite panoramic image, where the [[Biology:Maxilla|maxilla]] and mandible are in the focal trough and the structures that are superficial and deep to the trough are blurred.

Other nonproprietary names for a panoramic radiograph are '''dental panoramic radiograph''' and '''pantomogram'''; Abbreviations include '''PAN''', '''DPR''', '''OPT''', and '''OPG''' (the latter, based on genericizing a trade name, are often avoided in medical editing).

==Types==
Dental panoramic [[Physics:Radiography|radiography]] equipment consists of a horizontal rotating arm which holds an X-ray source and a moving film mechanism (carrying a film) arranged at opposed extremities. The patient's skull sits between the X-ray generator and the film. The [[Physics:X-ray|X-ray]] source is rectangular collimated beam.<ref>{{cite web|last1=Langlais|first1=Robert|title=RECTANGULAR COLLIMATION No longer a matter of choice!|url=https://www.examnotess.com/2021/06/what-is-orthopantomography-opg.html}}</ref> Also the height of that beam covers the mandibles and the [[Biology:Maxilla|maxilla]] regions. The arm moves and its movement may be described as a rotation around an instant center which shifts on a dedicated [[Physics:Trajectory|trajectory]].

The manufacturers propose different solutions for moving the arm, trying to maintain constant distance between the teeth to the film and generator. Also those moving solutions try to project the teeth [[Earth:Arch|arch]] as orthogonally as possible. It is impossible to select an ideal movement as the anatomy varies very much from person to person. Finally a [[Compromise|compromise]] is selected by each manufacturer and results in [[Physics:Magnification|magnification]] factors which vary strongly along the film (15%-30%). The patient positioning is very critical in regard to both sharpness and distortions.{{Citation needed|date=March 2021}}

===Films===
There are two kinds of film moving mechanisms, one using a sliding flat cassette which holds the film, and another using a rotating cylinder around which the film is wound. There are two standard sizes for dental panoramic films: 30&nbsp;cm × 12&nbsp;cm (12″ × 5″) and 30&nbsp;cm x 15&nbsp;cm (12″ × 6″). The smaller size film receives 8% less X-ray [[Physics:Dosimetry|dosage]] on it compared to the bigger size.

===Digital===
Dental X-rays' radiology is moving from film technology (involving a chemical developing process) to '''digital X-ray''' technology, which is based on electronic sensors and [[Computer|computer]]s. One of the principal advantages compared to film based systems is the much greater [[Exposure latitude|exposure latitude]]. This means many fewer repeated scans, which reduces costs and also reduces patient exposure to [[Physics:Radiation|radiation]]. Lost X-rays can also be reprinted if the digital file is saved. Other significant advantages include instantly viewable images, the ability to enhance images, the ability to email images to practitioners and clients (without needing to digitize them first), easy and reliable document handling, reduced X-ray exposure, that no [[Engineering:Darkroom|darkroom]] is required, and that no chemicals are used.

One particular type of digital system uses a photostimulable phosphor plate (aka PSP - Phosphor Plate) in place of the film. After X-ray exposure the plate (sheet) is placed in a special [[Social:Image scanner|scanner]] where the [[Engineering:Latency (engineering)|latent]] formed image is retrieved point by point and digitized, using a laser light scanning. The digitized images are stored and displayed on the computer screen. This method is in between old film based technology and the current direct digital imaging technology. It is similar to the film process because it involves the same image support handling and differs because the chemical development process is replaced by the scanning process. This is not much faster than film processing and the [[Physics:Optical resolution|resolution]] and sensitivity performances are contested. However it has the clear advantage of being able to fit with any existing equipment without any modification because it replaces just the existing film.

Also sometimes the term "digital X-rays" is used to designate the scanned film documents which further are handled by computers.

The other types of digital imaging technologies use electronic sensors. A majority of them first convert the X-rays in light (using a GdO2S or [[Chemistry:Caesium iodide|CsI]] layer) which is further captured using a [[Engineering:Charge-coupled device|CCD]] or a [[Engineering:CMOS|CMOS]] image sensor. Few of them use a hybrid [[Analog-to-digital converter|analog-to-digital]] arrangement which first converts the X-ray into [[Physics:Electricity|electricity]] (using a [[Chemistry:Cadmium telluride|CdTe]] layer) and then this electricity is rendered as an image by a reading section based on CMOS technology.

In current state-of-the-art digital systems, the image quality is vastly superior to conventional film-based systems. The latest advancements have also seen the addition on Cone Beam 3D Technology to standard digital panoramic devices.

==Indications==
[[File:PAN TEETH.jpg|thumbnail|right|Panoramic radiograph showing horizontally impacted lower wisdom teeth.]]
[[File:Simple mandible fracture.jpg|thumb|Minimally-displaced fracture in right mandibular. Arrow marks fracture, root canal on central incisor, teeth to the left of fracture do not touch]]
[[File:Stafne defect panorex.jpg|thumbnail|right|Panoramic radiograph showing Stafne defect (arrowed).]]
[[File:JawCyst (with arrows).jpg|thumbnail|right|Dental panoramic radiograph showing dentigerous cyst (arrowed).]]
Orthopantomograms (OPTs) are used by health care professionals to provide information on:

* Impacted wisdom teeth diagnosis and treatment planning - the most common use is to determine the status of wisdom teeth and trauma to the jaws.
* Periodontal [[Biology:Bone|bone]] loss and periapical involvement.
* Finding the source of dental [[Medicine:Pain|pain]], and when carrying out tooth-by-tooth diagnosis.
* Assessment for the placement of dental [[Medicine:Implant|implant]]s
* Orthodontic assessment. pre and post operative
* Diagnosis of developmental anomalies such as [[Medicine:Cherubism|cherubism]], cleido cranial dysplasia
* [[Medicine:Carcinoma|Carcinoma]] in relation to the jaws
* Temporomandibular joint dysfunctions and ankylosis.
* Diagnosis of [[Medicine:Osteosarcoma|osteosarcoma]], ameloblastoma, renal [[Medicine:Osteodystrophy|osteodystrophy]] affecting jaws and hypophosphatemia.
* Diagnosis, and pre- and post-surgical assessment of [[Medicine:Dental trauma|oral]] and maxillofacial trauma, e.g. dentoalveolar fractures and [[Medicine:Mandibular fracture|mandibular fracture]]s.
* Salivary stones (Sialolithiasis).
* Other diagnostic and treatment applications.<ref>Dental Radiographic Examinations: Recommendations For Patient Selection And Limiting Radiation Exposure. Am Dent Assoc, U.S. Dept of Health and Human Services, FDA. Revised: 2012</ref>

==Mechanism==
Normally, the person bites on a plastic [[Engineering:Spatula|spatula]] so that all the teeth, especially the [[Medicine:Crown (tooth)|crowns]], can be viewed individually. The whole orthopantomogram process takes about one [[Minute|minute]]. The patient's actual radiation exposure time varies between 5.5 and 22 seconds for the machine’s excursion around the skull.

The collimation of the machine means that, while rotating, the X-rays project only a limited portion of the [[Biology:Anatomy|anatomy]] onto the film at any given instant but, as the rotation progresses around the skull, a composite picture of the maxillo-facial block is created. While the arm rotates, the film moves in a such way that the projected partial skull image (limited by the beam section) scrolls over it and exposes it entirely. Not all of the overlapping individual images projected on the film have the same magnification because the beam is [[Physics:Beam divergence|divergent]] and the images have differing focus points. Also not all the element images move with the same [[Physics:Velocity|velocity]] on the target film as some of them are more distant from and others closer to the instant rotation center. The velocity of the film is controlled in such fashion to fit exactly the velocity of projection of the anatomical elements of the dental arch side which is closest to the film. Therefore, they are recorded sharply while the elements in different places are recorded blurred as they scroll at different velocity.

The dental panoramic image suffers from important distortions because a vertical [[Engineering:Zoom lens|zoom]] and a horizontal zoom both vary differently along the image. The vertical and horizontal zooms are determined by the relative position of the recorded element versus film and generator. Features closer to the generator receive more vertical zoom. The horizontal zoom is also dependent on the relative position of the element to the focal path. Features inside the focal path arch receive more horizontal zoom and are blurred; features outside receive less horizontal zoom and are blurred.

The result is an image showing sharply the section along the mandible arch, and blurred elsewhere. For example, the more radio-opaque anatomical region, the cervical vertebrae (neck), shows as a wide and blurred vertical pillar overlapping the front teeth. The path where the anatomical elements are recorded sharply is called "focal path".

===Principal advantage of panoramic images===
* Broad coverage of facial bone and teeth
* Low patient radiation dose
* Convenience of examination for the patient (films need not be placed inside the mouth)
* Ability to be used in patients who cannot open the mouth or when the opening is restricted e.g.: due to trismus
* Short time required for making the image
* Patient's ready understandability of panoramic films, making them a useful visual aid in patient education and case presentation.
* Easy to store compared to the large set of intra oral x-rays which are typically used.<ref>Stuart C. White, Micheal J Pharoh, Oral Radiology and Interpretation Mosby 2005</ref>

==Preparation==
Persons who are to undergo panoramic radiography usually are required to remove any earrings, jewellery, hair pins, glasses, dentures or orthodontic appliances.<ref name="Whaites 2007">{{cite book|vauthors = Whaites E, (( (foreword by Cawson RA)))|title=Essentials of dental radiography and radiology|url = https://archive.org/details/essentialsdental00bdse_341|url-access = limited|year=2007|publisher=Churchill Livingstone|location=Edinburgh|isbn=978-0-443-10168-7|pages=[https://archive.org/details/essentialsdental00bdse_341/page/n200 187]–206|edition=4th}}</ref> If these articles are not removed, they may create artifacts on the image (especially if they contain metal) and reduce its usefulness. There is also a need for the person to stay absolutely still during the 18 or so second cycle it takes for the machine to expose the film. For this reason, radiographers often explain to the person beforehand how the machine will move.<ref name="Whaites 2007" />

==Adverse effects==
Like any medical imaging utilizing [[Physics:Ionizing radiation|ionizing radiation]], there will be a minute degree of direct ionizing damage and indirect damage from [[Biology:Free radical|free radical]]s created during the ionization of water molecules within cells. A rough estimate of the risk of fatal cancer from a panoramic radiograph is about 1 in 20,000,000.<ref name="Whaites 2007" /> The age of the person being imaged also alters the risk, with younger people having a slightly higher risk. E.g. the 1 in 20,000,000 risk would be doubled for someone in the 1-10 age group (1 in 10,000,000).<ref name="Whaites 2007" />

==History==

===Historical milestones for digital panoramic systems===
1985–1991 – The first attempt to build a dental digital panoramic was of McDavid et al. at UTHSCSA.<ref>{{Cite web|url=http://www.google.com/patents/US5018177|title=Apparatus and method for producing digital panoramic x-ray images}}</ref> Their idea was based on a linear pixel array(single pixel column) sensor which was not appropriate for such an application because: a) there is no tomographic effect; b) huge difficulties to collimate the X-rays beam and to control the X-ray dose delivered to the patient; c) poor generator efficiency.<br/>
[[File:RotatingPan.gif|thumb|right|DXIS - real time display]]
1995 – DXIS, the first dental digital panoramic X-rays system available on the market, created by Catalin Stoichita at [http://www.dxis-net.com Signet (France)]. DXIS targeted to retrofit all the panoramic models.<br/>
1997 – SIDEXIS, of [[Company:Siemens|Siemens]] (currently [http://www.sirona.com Sirona Dental Systems], Germany) offered a digital option for Ortophos Plus panoramic unit, DigiPan of Trophy Radiology (France) offered a digital option  for the OP100 panoramic made by Instrumentarium (Finland).<br/>
1998–2004 – many panoramic manufacturers offered their own digital systems.

==Research==
[[Image:X-ray64A.JPG|thumb|right|alt=X-ray64A|Arrows point to two vertical white lines which is how calcifications in the first part (proximal component) of the internal carotid artery appear on panoramic radiographs.]]
[[Image:X-ray65B.JPG|thumb|right|alt=X-ray64B|A line drawing depicting a panoramic radiograph with an ovoid atheroma in the bifurcation region of the common carotid artery (CCA) as it bifurcates (divides) in the neck into the internal carotid artery (ICA) which supplies blood to the brain and the external carotid artery (ECA) which supplies blood to the face and mouth.]]
Panoramic radiographs have the capability to demonstrate a portion of the neck and display atheromas (calcifications in the carotid artery) which are an indication of both local and generalized (systemic) [[Medicine:Atherosclerosis|atherosclerosis]]. Atherosclerosis of the [[Biology:Coronary arteries|coronary arteries]] leading to [[Medicine:Myocardial infarction|myocardial infarction]] (heart attack), and atherosclerosis of the carotid artery leading to [[Medicine:Stroke|stroke]] are the number one and number three most common causes of death in the United States.<ref name="ref3">American Heart Association‚Äôs Heart Disease and Stroke Statistics‚Äî2010 Update [http://www.americanheart.org/downloadable/heart/1265665152970DS-3241%20HeartStrokeUpdate_2010.pdf]</ref>

There is interest to look at panoramic radiographs as a screening tool, however further data is needed with regards if it is able to make a meaningful difference in outcomes.<ref>{{cite journal|last=Roldán-Chicano|first=R|author2=Oñate-Sánchez, RE |author3=López-Castaño, F |author4=Cabrerizo-Merino, MC |author5= Martínez-López, F |title=Panoramic radiograph as a method for detecting calcified atheroma plaques. Review of literature|journal=Medicina Oral, Patologia Oral y Cirugia Bucal|date=May 1, 2006|volume=11|issue=3|pages=E261–6|pmid=16648765}}</ref>

=== Epidemiology: general public and high risk groups ===

Additional research projects have further determined the prevalence rate of these atheromas in the general population (3–5%)<ref name="ref6">{{cite journal |pages=635–40 |issue=5 |year=2005 |last1=Friedlander |pmid=15966651 |volume=136 |first1=AH |journal=Journal of the American Dental Association |last2=Garrett |first2=NR |last3=Chin |first3=EE |last4=Baker |first4=JD |title=Ultrasonographic confirmation of carotid artery atheromas diagnosed via panoramic radiography |url=http://jada.ada.org/cgi/reprint/136/5/635 |doi=10.14219/jada.archive.2005.0235 |access-date=2010-12-30 |archive-url=https://web.archive.org/web/20100623041127/http://jada.ada.org/cgi/reprint/136/5/635 |archive-date=2010-06-23 |url-status=dead }}</ref><ref>{{cite journal|last1=Almog|first1=DM|last2=Illig|first2=KA|last3=Carter|first3=LC|last4=Friedlander|first4=AH|last5=Brooks|first5=SL|last6=Grimes|first6=RM|title=Diagnosis of non-dental conditions. Carotid artery calcifications on panoramic radiographs identify patients at risk for stroke|journal=The New York State Dental Journal|date=November 2004|volume=70|issue=8|pages=20–5|pmid=15615333}}</ref> and among high-risk groups (over 25% in: recent stroke victims,<ref name="ref7">{{cite journal |doi=10.1016/0030-4220(94)90332-8 |last1=Friedlander |first1=AH |last2=Manesh |first2=F |last3=Wasterlain |first3=CG |title=Prevalence of detectable carotid artery calcifications on panoramic radiographs of recent stroke victims |journal=Oral Surgery, Oral Medicine, and Oral Pathology |volume=77 |issue=6 |pages=669–73 |year=1994 |pmid=8065736}}</ref> individuals with [[Medicine:Obstructive sleep apnea|obstructive sleep apnea]] syndrome,<ref name="ref8">{{cite journal |last1=Friedlander |first1=AH |last2=Yueh |first2=R |last3=Littner |first3=MR |title=The prevalence of calcified carotid artery atheromas in patients with obstructive sleep apnea syndrome |journal=Journal of Oral and Maxillofacial Surgery |volume=56 |issue=8 |pages=950–4 |year=1998 |pmid=9710189 |doi=10.1016/s0278-2391(98)90657-7}}</ref><ref name="ref9">{{cite journal |last1=Friedlander |first1=AH |last2=Friedlander |first2=IK |last3=Yueh |first3=R |last4=Littner |first4=MR |title=The prevalence of carotid atheromas seen on panoramic radiographs of patients with obstructive sleep apnea and their relation to risk factors for atherosclerosis |journal=Journal of Oral and Maxillofacial Surgery |volume=57 |issue=5 |pages=516–21; discussion 521–2 |year=1999 |pmid=10319824 |doi=10.1016/s0278-2391(99)90065-4}}</ref><ref name=Alves14>{{cite journal|last1=Alves|first1=N|last2=Deana|first2=NF|last3=Garay|first3=I|title=Detection of common carotid artery calcifications on panoramic radiographs: prevalence and reliability.|journal=International Journal of Clinical and Experimental Medicine|date=2014|volume=7|issue=8|pages=1931–9|pmid=25232373|pmc=4161533}}</ref> [[Medicine:Menopause|postmenopausal]] women,<ref name="ref10">{{cite journal |pages=1130–6 |last1=Friedlander |year=2001 |issue=8 |pmid=11575022 |volume=132 |first1=AH |journal=Journal of the American Dental Association |last2=Altman |first2=L |title=Carotid artery atheromas in postmenopausal women. Their prevalence on panoramic radiographs and their relationship to atherogenic risk factors |url=http://jada.ada.org/cgi/reprint/132/8/1130 |doi=10.14219/jada.archive.2001.0340 |access-date=2010-12-30 |archive-url=https://web.archive.org/web/20090523083256/http://jada.ada.org/cgi/reprint/132/8/1130 |archive-date=2009-05-23 |url-status=dead }}</ref>{{primary source inline|date=April 2013}} [[Medicine:Type 2 diabetes|type 2 diabetics]],<ref name="ref11">{{cite journal |pages=1516–23 |issue=11 |last1=Friedlander |year=2002 |volume=133 |pmid=12462696 |first1=AH |journal=Journal of the American Dental Association |last2=Garrett |first2=NR |last3=Norman |first3=DC |title=The prevalence of calcified carotid artery atheromas on the panoramic radiographs of patients with type 2 diabetes mellitus |url=http://jada.ada.org/cgi/reprint/133/11/1516 |doi=10.14219/jada.archive.2002.0083 |access-date=2010-12-30 |archive-url=https://web.archive.org/web/20080908053808/http://jada.ada.org/cgi/reprint/133/11/1516 |archive-date=2008-09-08 |url-status=dead }}</ref><ref name=Alves14/><ref name="ref12">{{cite journal |doi=10.1016/S1079-2104(00)70122-3 |last1=Friedlander |first1=AH |last2=Maeder |first2=LA |title=The prevalence of calcified carotid artery atheromas on the panoramic radiographs of patients with type 2 diabetes mellitus |journal=Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics |volume=89 |issue=4 |pages=420–4 |year=2000 |pmid=10760724|url=https://zenodo.org/record/1260196 }}</ref> individuals with [[Medicine:Dilated cardiomyopathy|dilated cardiomyopathy]],<ref name="ref13">{{cite journal |last1=Sung |first1=EC |last2=Friedlander |first2=AH |last3=Kobashigawa |first3=JA |title=The prevalence of calcified carotid atheromas on the panoramic radiographs of patients with dilated cardiomyopathy |journal=Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics |volume=97 |issue=3 |pages=404–7 |year=2004 |pmid=15024368 |doi= 10.1016/j.tripleo.2003.08.025}}</ref><ref name=Alves14/> and among individuals who have received radiotherapy directed at the neck,<ref name="ref14">{{cite journal |last1=Friedlander |first1=AH |last2=Eichstaedt |first2=RM |last3=Friedlander |first3=IK |last4=Lambert |first4=PM |title=Detection of radiation-induced, accelerated atherosclerosis in patients with osteoradionecrosis by panoramic radiography |journal=Journal of Oral and Maxillofacial Surgery |volume=56 |issue=4 |pages=455–9 |year=1998 |pmid=9541345 |doi=10.1016/s0278-2391(98)90712-1|doi-access=free }}</ref>{{primary source inline|date=April 2013}}<ref name="ref15">{{cite journal |doi=10.1016/S1079-2104(98)90020-8 |last1=Friedlander |first1=AH |last2=August |first2=M |title=The role of panoramic radiography in determining an increased risk of cervical atheromas in patients treated with therapeutic irradiation |journal=Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics |volume=85 |issue=3 |pages=339–44 |year=1998 |pmid=9540095}}</ref>{{primary source inline|date=April 2013}}). These findings have been corroborated by other several other researchers.<ref name="ref16">{{cite journal |pages=977–84 |issue=7 |year=1997 |last1=Carter |pmid=9231602 |volume=128 |first1=LC |journal=Journal of the American Dental Association |last2=Haller |first2=AD |last3=Nadarajah |first3=V |last4=Calamel |first4=AD |last5=Aguirre |first5=A |title=Use of panoramic radiography among an ambulatory dental population to detect patients at risk of stroke |url=http://jada.ada.org/cgi/reprint/128/7/977 |doi=10.14219/jada.archive.1997.0338 |access-date=2010-12-30 |archive-url=https://web.archive.org/web/20081123073250/http://jada.ada.org/cgi/reprint/128/7/977 |archive-date=2008-11-23 |url-status=dead }}</ref><ref name="ref17">{{cite journal |last1=Lewis |first1=DA |last2=Brooks |first2=SL |title=Cartoid artery calcification in a general dental population: a retrospective study of panoramic radiographs |journal=General Dentistry |volume=47 |issue=1 |pages=98–103 |year=1999 |pmid=10321159}}</ref><ref name="ref18">{{cite journal |pages=1593–7 |issue=11 |year=2000 |last1=Almog |pmid=11103578 |volume=131 |first1=DM |journal=Journal of the American Dental Association |last2=Illig |first2=KA |last3=Khin |first3=M |last4=Green |first4=RM |title=Unrecognized carotid artery stenosis discovered by calcifications on a panoramic radiograph |url=http://jada.ada.org/cgi/reprint/131/11/1593 |doi=10.14219/jada.archive.2000.0088 |access-date=2010-12-30 |archive-url=https://web.archive.org/web/20090523073557/http://jada.ada.org/cgi/reprint/131/11/1593 |archive-date=2009-05-23 |url-status=dead }}</ref><ref name="ref19">{{cite journal |last1=Farman |first1=AG |last2=Farman |first2=TT |last3=Khan |first3=Z |last4=Chen |first4=Z |last5=Carter |first5=LC |last6=Friedlander |first6=AH |title=The role of the dentist in detection of carotid atherosclerosis |journal=South African Dental Journal |volume=56 |issue=11 |pages=549–53 |year=2001 |pmid=11885436}}</ref><ref name=Alves14/>

=== Dental infection and atherosclerosis ===

Atherosclerosis is attributed to risk factors that include cigarette smoking, hyperlipidemia, obesity, [[Medicine:Diabetes mellitus|diabetes mellitus]], and [[Medicine:Hypertension|hypertension]] (high blood pressure). These factors, however, do not fully account for the risk of disease. Atherosclerosis has been conceptualized as a chronic inflammatory response to endothelial cell injury<ref name="ref20">{{cite journal |last1=Epstein |first1=Franklin H. |last2=Ross |first2=Russell |title=Atherosclerosis — an Inflammatory Disease |journal=New England Journal of Medicine |volume=340 |issue=2 |pages=115–26 |year=1999 |pmid=9887164 |doi=10.1056/NEJM199901143400207}}</ref> and dysfunction possibly arising from chronic dental infection. In 2010, using the previously validated Mattila panoramic radiographic index to quantify the totality of dental infection (i.e., periapical and furcal lesions, pericoronitis sites, carious tooth roots, teeth with [[Biology:Pulp (tooth)|pulpal]] caries, and vertical bony defects), Friedlander’s group determined that individuals with carotid artery atheromas on their panoramic radiographs had significantly greater amounts of dental infection/inflammation than atherogenic risk-matched controls devoid of radiographic atheromas.<ref name="ref21">{{cite journal|last1=Mattila|first1=KJ|last2=Nieminen|first2=MS|last3=Valtonen|first3=VV|last4=Rasi|first4=VP|last5=Kesäniemi|first5=YA|last6=Syrjälä|first6=SL|last7=Jungell|first7=PS|last8=Isoluoma|first8=M|last9=Hietaniemi|first9=K|last10=Jokinen|first10=MJ|title=Association between dental health and acute myocardial infarction|journal=BMJ (Clinical Research Ed.)|date=25 March 1989|volume=298|issue=6676|pages=779–81|doi=10.1136/bmj.298.6676.779|pmid=2496855|pmc=1836063|display-authors=8}}</ref>{{primary source inline|date=April 2013}}<ref name="ref22">{{cite journal |last1=Friedlander |first1=AH |last2=Sung |first2=EC |last3=Chung |first3=EM |last4=Garrett |first4=NR |title=Radiographic quantification of chronic dental infection and its relationship to the atherosclerotic process in the carotid arteries |journal=Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics |volume=109 |issue=4 |pages=615–21 |year=2010 |pmid=20097109 |doi=10.1016/j.tripleo.2009.10.036}}</ref>{{primary source inline|date=April 2013}} While the Mattila index had been previously used to relate the extent of dental infection to [[Medicine:Coronary artery disease|coronary artery disease]], this research is the first to link the full range of dental disease that it measures to panoramic radiographs evidencing calcified carotid artery atherosclerosis.

==See also==
*Oral and maxillofacial radiology

== References ==
{{Reflist}}

{{medical imaging}}

[[Category:Dentistry]]

{{Sourceattribution|Panoramic radiograph|1}}