View source for Medicine:Cerebral hyperperfusion syndrome

'''Cerebral hyperperfusion syndrome''', also known as '''reperfusion syndrome''', is a dysregulated state of cerebral blood flow following the restoration of arterial blood flow to the brain, usually following treatment of [[Medicine:Carotid artery stenosis|carotid artery stenosis]].<ref>{{cite journal |last1=Farooq |first1=MU |last2=Goshgarian |first2=C |last3=Min |first3=J |last4=Gorelick |first4=PB |title=Pathophysiology and management of reperfusion injury and hyperperfusion syndrome after carotid endarterectomy and carotid artery stenting. |journal=Experimental & Translational Stroke Medicine |date=2016 |volume=8 |issue=1 |pages=7 |doi=10.1186/s13231-016-0021-2 |pmid=27602202|pmc=5012059 |doi-access=free }}</ref> Risk factors include hypertension, particularly high blood pressures in the first few days following revascularization and bilateral stenosis.

==Symptoms==
The first symptom is usually severe headache, and a headache in the setting of recent [[Medicine:Carotid endarterectomy|carotid endarterectomy]] or [[Medicine:Carotid stenting|carotid stenting]] should prompt a return to the hospital and close attention by clinicians. Symptoms may progress to seizures and [[Medicine:Coma|coma]] in severe cases.

==Treatment==
Treatment is control of the blood pressure, often with continuous intravenous antihypertensives medicines in the intensive care setting.<ref>{{cite journal |last1=Kirchoff-Torres |first1=KF |last2=Bakradze |first2=E |title=Cerebral Hyperperfusion Syndrome After Carotid Revascularization and Acute Ischemic Stroke. |journal=Current Pain and Headache Reports |date=19 March 2018 |volume=22 |issue=4 |pages=24 |doi=10.1007/s11916-018-0678-4 |pmid=29556806}}</ref> Seizures may require treatment with [[Chemistry:Anticonvulsant|anti-seizure medication]].

==References==
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[[Category:Cardiovascular physiology]]
[[Category:Neurotrauma]]

{{Sourceattribution|Cerebral hyperperfusion syndrome}}