View source for Chemistry:Inverted ligand field theory

[[File:MO diagrams ligand field.png|thumb|391x391px|Ligand field molecular orbital (MO) bonding regimes for Werner-type (left), covalent (middle), and inverted ligand fields.<ref name=":4" />]]
[[File:TM-MG boundary.png|thumb|At the transition-metal - main group boundary, metal cations in organometallic complexes are more electronegative than the relatively more electropositive ligand atoms which act as z-type ligands.|389x389px]]
'''Inverted ligand field theory (ILFT)''' describes a phenomenon in the bonding of [[Chemistry:Coordination complex|coordination complex]]es where the lowest unoccupied [[Chemistry:Molecular orbital|molecular orbital]] is primarily of ligand character.<ref name=":0">{{Cite journal |last1=Hoffmann |first1=Roald |last2=Alvarez |first2=Santiago |last3=Mealli |first3=Carlo |last4=Falceto |first4=Andrés |last5=Cahill |first5=Thomas J. |last6=Zeng |first6=Tao |last7=Manca |first7=Gabriele |date=2016-07-27 |title=From Widely Accepted Concepts in Coordination Chemistry to Inverted Ligand Fields |url=https://pubs.acs.org/doi/10.1021/acs.chemrev.6b00251 |journal=Chemical Reviews |language=en |volume=116 |issue=14 |pages=8173–8192 |doi=10.1021/acs.chemrev.6b00251 |pmid=27398715 |issn=0009-2665}}</ref><ref name=":4">{{Cite journal |last1=DiMucci |first1=Ida M. |last2=Lukens |first2=James T. |last3=Chatterjee |first3=Sudipta |last4=Carsch |first4=Kurtis M. |last5=Titus |first5=Charles J. |last6=Lee |first6=Sang Jun |last7=Nordlund |first7=Dennis |last8=Betley |first8=Theodore A. |last9=MacMillan |first9=Samantha N. |last10=Lancaster |first10=Kyle M. |date=2019-11-20 |title=The Myth of d 8 Copper(III) |journal=Journal of the American Chemical Society |language=en |volume=141 |issue=46 |pages=18508–18520 |doi=10.1021/jacs.9b09016 |issn=0002-7863 |pmc=7256958 |pmid=31710466}}</ref> This is contrary to the traditional [[Chemistry:Ligand field theory|ligand field theory]] or [[Physics:Crystal field theory|crystal field theory]] picture and arises from the breaking down of the assumption that in [[Chemistry:Organometallic chemistry|organometallic]] complexes, ligands are more electronegative and have frontier orbitals below those of the d orbitals of electropositive metals.<ref>{{Cite book |last=Albright |first=Thomas A. |url=https://www.worldcat.org/oclc/823294395 |title=Orbital interactions in chemistry |date=2013 |others=Jeremy K. Burdett, Myung-Hwan Whangbo |isbn=978-0-471-08039-8 |edition=2nd |location=Hoboken, New Jersey |oclc=823294395}}</ref><ref name=":1">{{Cite journal |last1=Griffith |first1=J. S. |last2=Orgel |first2=L. E. |date=1957-01-01 |title=Ligand-field theory |url=https://pubs.rsc.org/en/content/articlelanding/1957/qr/qr9571100381 |journal=Quarterly Reviews, Chemical Society |language=en |volume=11 |issue=4 |pages=381–393 |doi=10.1039/QR9571100381 |issn=0009-2681}}</ref> As we move to the right of the d-block and approach the transition-metal - main group boundary, the d orbitals become more core-like, making their cations more electronegative. This decreases their energies and eventually arrives at a point where they are lower in energy than the ligand frontier orbitals.<ref name=":0" /> Here the ligand field inverts so that the bonding orbitals are more metal-based, and antibonding orbitals more ligand-based. The relative arrangement of the d orbitals are also inverted in complexes displaying this inverted ligand field.<ref name=":0" /> This has consequences in our understanding of accessible metal oxidation states, and the reactivity of complexes exhibiting ILFT.

== History ==
[[File:Cu-CF3-4-1.gif|thumb|Cu(CF<sub>3</sub>)<sub>4</sub><sup>-</sup> square planar structure]]
The first example of an inverted ligand field was demonstrated in paper form 1995 by James Snyder.<ref name=":2">{{Cite journal |last=Snyder |first=James |title=Distinguishing Copper d8 and d10 Configurations in a Highly Ionic Complex; A Nonformal Metal Oxidation State |url=https://onlinelibrary.wiley.com/doi/10.1002/anie.199509862 |journal=Angewandte Chemie International Edition in English |year=1995 |volume=35 |issue=9 |pages=986–987 |doi=10.1002/anie.199509862 |via=Wiley}}</ref> In this theoretical paper, Snyder proposed that the [Cu(CF<sub>3</sub>)<sub>4</sub>]<sup>-</sup> complexes reported by Naumann et al. and assigned a formal oxidation state of 3+ at the copper<ref>{{Cite journal |last1=Naumann |first1=Dieter |last2=Roy |first2=Thomas |last3=Tebbe |first3=Karl-Friedrich |last4=Crump |first4=Wolfgang |date=1993-10-10 |title=Synthesis and Structure of Surprisingly Stable Tetrakis(trifluoromethyl)cuprate(III) Salts |url=http://dx.doi.org/10.1002/anie.199314821 |journal=Angewandte Chemie International Edition in English |volume=32 |issue=10 |pages=1482–1483 |doi=10.1002/anie.199314821 |issn=0570-0833}}</ref> would be better thought of as Cu(I). By comparing the d-orbital occupation, calculated charges and orbital population of [Cu(CF<sub>3</sub>)<sub>4</sub>]<sup>-</sup> "Cu(III)" complex and the formally Cu(I) [Cu(CH<sub>3</sub>)<sub>2</sub>]<sup>-</sup> complex, they illustrated how the former could be better described as a d10 copper complex experiencing two electron donation from the CF<sub>3</sub><sup>-</sup> ligands.<ref name=":2" /> The phenomenon, termed an inverted ligand field by Roald Hoffman, began to be described by Aullón and Alvarez as they identified this phenonmenon as being a result of relative electronegativities.<ref>{{Cite journal |last1=Aullón |first1=Gabriel |last2=Alvarez |first2=Santiago |date=2009-05-01 |title=Oxidation states, atomic charges and orbital populations in transition metal complexes |url=https://doi.org/10.1007/s00214-009-0537-9 |journal=Theoretical Chemistry Accounts |language=en |volume=123 |issue=1 |pages=67–73 |doi=10.1007/s00214-009-0537-9 |s2cid=97419872 |issn=1432-2234}}</ref> Lancaster and co-workers later provided experimental evidence to support the assignment of this oxidation state. Using UV/visible/near IR spectroscopy, Cu K-edge X-ray absorption spectroscopy, and 1s2p resonant inelastic X-ray scattering in concert with density functional theory, multiplet theory, and multireference calculations, they were able to map the ground state electronic configuration. This showed that the lowest unoccupied orbital was of primarily trifluoromethyl character. This confirmed the presence of an inverted ligand field and started building experimental tools to probe this phenomenon.<ref name=":5">{{Cite journal |last1=Walroth |first1=Richard C. |last2=Lukens |first2=James T. |last3=MacMillan |first3=Samantha N. |last4=Finkelstein |first4=Kenneth D. |last5=Lancaster |first5=Kyle M. |date=2016-02-17 |title=Spectroscopic Evidence for a 3d 10 Ground State Electronic Configuration and Ligand Field Inversion in [Cu(CF 3 ) 4 ] 1– |url=https://pubs.acs.org/doi/10.1021/jacs.5b10819 |journal=Journal of the American Chemical Society |language=en |volume=138 |issue=6 |pages=1922–1931 |doi=10.1021/jacs.5b10819 |pmid=26844693 |issn=0002-7863}}</ref> Since the Snyder case, many other complexes of later transition metals have been shown to display inverted ligand field through both theoretical and experimental methods.

== Probing inverted ligand fields ==
Computational and experimental techniques have been imperative for the study of inverted ligand fields, especially when used in cooperatively.

=== Computational ===
Computational methods have played a large role in understanding the nature of bonding in both molecular and solid-state systems displaying inverted ligand fields. The Hoffman group has completed many calculations to probe occurrence of inverted ligand fields in varying systems.<ref>{{Cite journal |last1=Zheng |first1=Chong |last2=Hoffmann |first2=Roald |date=1989-03-01 |title=Conjugation in the 3-connected net: the aluminum diboride and thorium disilicide structures and their transition-metal derivatives |url=https://pubs.acs.org/doi/abs/10.1021/ic00305a015 |journal=Inorganic Chemistry |language=en |volume=28 |issue=6 |pages=1074–1080 |doi=10.1021/ic00305a015 |issn=0020-1669}}</ref> In a study of the absorption of CO on PtBi and PtBi2 surfaces, on an octahedral [Pt(BiH<sub>3</sub>)<sub>6</sub>]<sup>4+</sup> model with a Pt thought of having a formal 4+ oxidation state, the team found that the t<sub>2g</sub> metal orbitals were higher energy that the e<sub>g</sub> orbitals. This inversion of the d orbital ordering was attributed to the bismuth based ligands being higher in energy than the metal d orbitals.<ref>{{Cite journal |last1=Oana |first1=Melania |last2=Hoffmann |first2=Roald |last3=Abruña |first3=Héctor D. |last4=DiSalvo |first4=Francis J. |date=2005-01-01 |title=Adsorption of CO on PtBi2 and PtBi surfaces |url=https://www.sciencedirect.com/science/article/pii/S0039602804012877 |journal=Surface Science |language=en |volume=574 |issue=1 |pages=1–16 |doi=10.1016/j.susc.2004.09.045 |bibcode=2005SurSc.574....1O |issn=0039-6028}}</ref> In another study involving calculations on Ag(III) salt KAgF<sub>4</sub>, other Ag(II), and Ag(III) compounds, the Ag d orbitals were found to be below those of the fluoride ligand orbitals,<ref>{{Cite journal |last1=Grochala |first1=Wojciech |last2=Hoffmann |first2=Roald |date=2010-05-24 |title=ChemInform Abstract: Real and Hypothetical Intermediate-Valence AgII/AgIII and AgII/AgI Fluoride Systems as Potential Superconductors |url=http://dx.doi.org/10.1002/chin.200143247 |journal=ChemInform |volume=32 |issue=43 |pages=no |doi=10.1002/chin.200143247 |issn=0931-7597}}</ref> and was confirmed by Grochala and cowrokers by core and valence spectroscopies.<ref>{{Cite journal |last1=Grochala |first1=Wojciech |last2=Egdell |first2=Russ G. |last3=Edwards |first3=Peter P. |last4=Mazej |first4=Zoran |last5=Žemva |first5=Boris |date=2003-09-10 |title=On the Covalency of Silver-Fluorine Bonds in Compounds of Silver(I), Silver(II) and Silver(III) |url=http://dx.doi.org/10.1002/cphc.200300777 |journal=ChemPhysChem |volume=4 |issue=9 |pages=997–1001 |doi=10.1002/cphc.200300777 |pmid=14562447 |issn=1439-4235}}</ref>

The Mealli group developed the program Computer Aided Composition of Atomic Orbitals (CACAO) to provide visualised molecular orbitals analyses based on perturbation theory principles.<ref name=":3">{{Cite journal |last1=Mealli |first1=Carlo |last2=Proserpio |first2=Davide M. |date=1990-05-01 |title=MO theory made visible |url=http://dx.doi.org/10.1021/ed067p399 |journal=Journal of Chemical Education |volume=67 |issue=5 |pages=399 |doi=10.1021/ed067p399 |bibcode=1990JChEd..67..399M |issn=0021-9584}}</ref> This program successfully displayed orbital energy inversion with organometallic complexes containing electronegative metals such as Ni or Cu bound to electropositive ligand atoms such as B, Si, or Sn.<ref name=":3" /> In these cases the bonding was described as a ligand to metal dative bond or sigma backdonation.<ref>{{Cite journal |last1=Mealli |first1=Carlo |last2=Ghilardi |first2=Carlo A. |last3=Orlandini |first3=Annabella |date=1992-11-01 |title=Structural flexibility and bonding capabilities of the ligand np3 toward the transition metals |url=http://dx.doi.org/10.1016/0010-8545(92)80059-z |journal=Coordination Chemistry Reviews |volume=120 |pages=361–387 |doi=10.1016/0010-8545(92)80059-z |issn=0010-8545}}</ref>
[[File:CoP3 ILF.png|thumb|Interaction of the filled p band of P<sub>4</sub><sup>4-</sup>  ring sublattice with Co d block bands in CoP<sub>3</sub>.<ref name=":6" /><ref name=":0" />]]
Alvarez and coworkers used computational methods to illustrate ligand field inversion in the band structures of solid state materials. The group found that, contrary to the classical bonding scheme, in calculated MoNiP<sub>8</sub> band structures the e<sub>g</sub>-type orbitals of the octahedral nickel atom were found to be the major component of an occupied band below the t<sub>2g</sub> set.<ref>{{Cite journal |last1=LLUNELL |first1=M. |last2=ALVAREZ |first2=S. |last3=ALEMANY |first3=P. |last4=HOFFMANN |first4=R. |date=2010-08-04 |title=ChemInform Abstract: Electronic Structure, Bonding, and Electrical Properties of MoNiP8. |url=http://dx.doi.org/10.1002/chin.199646001 |journal=ChemInform |volume=27 |issue=46 |pages=no |doi=10.1002/chin.199646001 |issn=0931-7597}}</ref> Additionally, the band around the fermi level which included the Ni<sup>+</sup> antibonding orbitals were found to be mostly of phosphorus character, a clear example if an inverted ligand field. Similar observations were made in other solid state materials like the [[Chemistry:Skutterudite|skutterudite]] CoP<sub>3</sub> structure.<ref>{{Cite journal |last1=Llunell |first1=Miquel |last2=Alemany |first2=Pere |last3=Alvarez |first3=Santiago |last4=Zhukov |first4=Vladlen P. |last5=Vernes |first5=Andreas |date=1996-04-15 |title=Electronic structure and bonding in skutterudite-type phosphides |url=http://dx.doi.org/10.1103/physrevb.53.10605 |journal=Physical Review B |volume=53 |issue=16 |pages=10605–10609 |doi=10.1103/physrevb.53.10605 |pmid=9982624 |bibcode=1996PhRvB..5310605L |hdl=2445/10836 |issn=0163-1829}}</ref><ref name=":6">{{Cite journal |last1=Llunell |first1=Miquel |last2=Alvarez |first2=Santiago |last3=Alemany |first3=Pere |date=1998 |title=Skutterudite vs. ReO3 structures for MX3 solids: electronic requirements |url=http://dx.doi.org/10.1039/a708200b |journal=Journal of the Chemical Society, Dalton Transactions |issue=7 |pages=1195–1200 |doi=10.1039/a708200b |issn=0300-9246}}</ref> A consequence of the inverted ligand field in this case is that the conductivity in skutterudites is associated with the phosphorus rings rather than the metal atoms.

=== Experimental ===
[[Physics:X-ray absorption spectroscopy|X-ray absorption spectroscopy]] (XAS) has been a powerful tool in deducing the oxidation states of transition metals.<ref>{{Cite journal |last1=Glaser |first1=Thorsten |last2=Hedman |first2=Britt |last3=Hodgson |first3=Keith O. |last4=Solomon |first4=Edward I. |date=2001-03-06 |title=ChemInform Abstract: Ligand K-Edge X-Ray Absorption Spectroscopy: A Direct Probe of Ligand-Metal Covalency |url=http://dx.doi.org/10.1002/chin.200110300 |journal=ChemInform |volume=32 |issue=10 |pages=no |doi=10.1002/chin.200110300 |issn=0931-7597}}</ref> Energy shifts in XAS are higher due to the higher effective nuclear charge of atoms in higher oxidations, presumably due to the higher binding energy for deeper, more core-like electrons.<ref name=":0" />

Despite this being a very powerful technique, competing effects on the rising edge positions can make assignment difficult. It was initially thought that the weak, quadrupole-allowed pre-edge peak assigned as the Cu 1s to 3d transition could be used to distinguish between Cu(II) and Cu(III) with the features appearing at 8979 +/- 0.3 eV and 8981 +/- 0.5 eV, respectively.<ref>{{Cite journal |last1=DuBois |first1=Jennifer L. |last2=Mukherjee |first2=Pulakesh |last3=Stack |first3=T. D. P. |last4=Hedman |first4=Britt |last5=Solomon |first5=Edward I. |last6=Hodgson |first6=Keith O. |date=2000-06-01 |title=A Systematic K-edge X-ray Absorption Spectroscopic Study of Cu(III) Sites |url=http://dx.doi.org/10.1021/ja993134p |journal=Journal of the American Chemical Society |volume=122 |issue=24 |pages=5775–5787 |doi=10.1021/ja993134p |issn=0002-7863}}</ref> Ab initio calculations by Tomson, Wieghardt, and co-workers displayed that pre-peaks previously assigned as Cu(III) could be displayed by Cu(II) bearing complexes.<ref>{{Cite journal |last1=Tomson |first1=Neil C. |last2=Williams |first2=Kamille D. |last3=Dai |first3=Xuliang |last4=Sproules |first4=Stephen |last5=DeBeer |first5=Serena |last6=Warren |first6=Timothy H. |last7=Wieghardt |first7=Karl |date=2015 |title=Re-evaluating the Cu K pre-edge XAS transition in complexes with covalent metal–ligand interactions |url=http://dx.doi.org/10.1039/c4sc03294b |journal=Chemical Science |volume=6 |issue=4 |pages=2474–2487 |doi=10.1039/c4sc03294b |pmid=29308158 |pmc=5647745 |s2cid=246748080 |issn=2041-6520}}</ref> Many groups have displayed that metal K-edge XAS transitions involving ligand-localised acceptor orbitals, as well as spectral shifts from change in coordination environment, can make metal K-edge analysis less predictable.<ref>{{Cite journal |title=Xray Absorption Spectroscopy as a Probe of Ligand Noninnocence in Metallocorroles: The Case of Copper Corroles |url=http://dx.doi.org/10.1021/acs.inorgchem.9b00128.s001 |access-date=2023-03-12 |doi=10.1021/acs.inorgchem.9b00128.s001 |hdl=10037/18125 }}</ref><ref>{{Cite journal |last1=Walroth |first1=Richard C. |last2=Uebler |first2=Jacob W. H. |last3=Lancaster |first3=Kyle M. |date=2015 |title=Probing Cu<sup>I</sup> in homogeneous catalysis using high-energy-resolution fluorescence-detected X-ray absorption spectroscopy |url=http://dx.doi.org/10.1039/c5cc01827g |journal=Chemical Communications |volume=51 |issue=48 |pages=9864–9867 |doi=10.1039/c5cc01827g |pmid=25994112 |pmc=4540364 |issn=1359-7345}}</ref><ref>{{Cite journal |last1=Carsch |first1=Kurtis M. |last2=DiMucci |first2=Ida M. |last3=Iovan |first3=Diana A. |last4=Li |first4=Alex |last5=Zheng |first5=Shao-Liang |last6=Titus |first6=Charles J. |last7=Lee |first7=Sang Jun |last8=Irwin |first8=Kent D. |last9=Nordlund |first9=Dennis |last10=Lancaster |first10=Kyle M. |last11=Betley |first11=Theodore A. |date=2019-09-13 |title=Synthesis of a copper-supported triplet nitrene complex pertinent to copper-catalyzed amination |url=http://dx.doi.org/10.1126/science.aax4423 |journal=Science |volume=365 |issue=6458 |pages=1138–1143 |doi=10.1126/science.aax4423 |pmid=31515388 |pmc=7256962 |bibcode=2019Sci...365.1138C |issn=0036-8075}}</ref><ref>{{Cite journal |last1=KAU |first1=L.-S. |last2=SPIRA-SOLOMON |first2=D. J. |last3=PENNER-HAHN |first3=J. E. |last4=HODGSON |first4=K. O. |last5=SOLOMON |first5=E. I. |date=1988-02-09 |title=ChemInform Abstract: X-Ray Absorption Edge Determination of the Oxidation State and Coordination Number of Copper: Application to the Type 3 Site in Rhus vernicifera Laccase and Its Reaction with Oxygen |url=http://dx.doi.org/10.1002/chin.198806038 |journal=ChemInform |volume=19 |issue=6 |doi=10.1002/chin.198806038 |issn=0931-7597}}</ref>

The most sussessful use of K and L-edge XAS provide valuable information on the composition of molecular orbitals and display inverted ligand fields has been done in studies that made use of computational techniques in concert with experimental techniques. This was the case of the L<sub>2</sub>[Cu<sub>2</sub>(S<sub>2</sub>)<sub>''n''</sub>]<sup>2+</sup> complexes of York, Brown, and Tolman,<ref>{{Cite journal |last1=Sarangi |first1=Ritimukta |last2=York |first2=John T. |last3=Helton |first3=Matthew E. |last4=Fujisawa |first4=Kiyoshi |last5=Karlin |first5=Kenneth D. |last6=Tolman |first6=William B. |last7=Hodgson |first7=Keith O. |last8=Hedman |first8=Britt |last9=Solomon |first9=Edward I. |date=2008-01-01 |title=X-Ray Absorption Spectroscopic and Theoretical Studies on (L) 2 [Cu 2 (S 2 ) n ] 2+ Complexes: Disulfide versus Disulfide(•1−) Bonding |journal=Journal of the American Chemical Society |language=en |volume=130 |issue=2 |pages=676–686 |doi=10.1021/ja0762745 |issn=0002-7863 |pmc=2570853 |pmid=18076173}}</ref> and the Cu(CF<sub>3</sub>)<sup>4-</sup> by various groups including Hoffman,<ref name=":0" /> Overgaard,<ref>{{Cite journal |last=Overgaard |first=Jacob |date=2019-01-15 |title=Experimental X-ray Electron Density Study of Atomic Charges, Oxidation States, and Inverted Ligand Field in Cu(CF3)4– |url=https://doi.org/10.1021/acs.inorgchem.8b03226 |journal=Inorganic Chemistry |volume=58 |issue=3 |pages=2133–2139|doi=10.1021/acs.inorgchem.8b03226 |pmid=30645110 |hdl=2434/971202 |s2cid=58640050 }}</ref> and Lancaster.<ref name=":4" /><ref name=":5" />

Another experimental tool used to probe ligand field inversion includes [[Physics:Electron paramagnetic resonance|Electron paramagnetic resonance]] (ESR/EPR), which can provide information regarding the metal electronic configuration, the nature of the SOMO, and high resolution information on the ligands.<ref>{{Cite journal |last1=Kisgeropoulos |first1=Effie C. |last2=Manesis |first2=Anastasia C. |last3=Shafaat |first3=Hannah S. |date=2021-01-20 |title=Ligand Field Inversion as a Mechanism to Gate Bioorganometallic Reactivity: Investigating a Biochemical Model of Acetyl CoA Synthase Using Spectroscopy and Computation |url=https://pubs.acs.org/doi/10.1021/jacs.0c10135 |journal=Journal of the American Chemical Society |language=en |volume=143 |issue=2 |pages=849–867 |doi=10.1021/jacs.0c10135 |pmid=33415980 |s2cid=231195483 |issn=0002-7863}}</ref>

== Impact of charge and geometry ==
[[File:MO (Cu(CF2)4)n-.png|thumb|333x333px|MO diagrams of frontier orbitals of [Cu(CF<sub>3</sub>)<sub>4</sub>)<sup>n-</sup> anions.<ref name=":0" /> ]]
Changes in both charge and geometry of organometallic complexes can greatly vary the energies of molecular orbitals and can therefore dictate the likelihood of observing an inverted ligand field. Hoffman and coworkers explored the impact of these variables by calculating the atomic composition of molecular orbitals for mono- di- and trianion copper complexes.<ref name=":0" /> The square planar monoanion displayed the reported ligand field inversion. The "Cu(II)" which has an intermediate square planar to tetrahedral geometry also displayed this feature with the antibonding t<sub>2</sub>-derived orbital being mostly of ligand character and the x<sup>2</sup>-y<sup>2</sup> orbital being the lowest molecular orbital of the d block. The tetrahedral trianion showed a return to the Werner-type ligand field.<ref name=":0" /> By modulating the geometry of the "Cu(II)" species and displaying the change in energies of MO on [[Chemistry:Walsh diagram|walsh diagram]]s, the group was able to show how the complex could display both a classical and inverted ligand field when in T<sub>d</sub> and SP geometry respectively.<ref name=":0" /> Additional calculations on the Cu(I) with non-tetrahedral geometry also displayed an inverted ligand field. This indicated the importance of not just oxidation state but geometry in determining the inversion of a ligand field.
	
[[File:Cu CF3 4 n Frontier orbitals.png|center|thumb|720x720px|Frontier orbitals of mono-, di-, and trianionic [Cu(CF<sub>3</sub>)<sub>4</sub><nowiki>]</nowiki><sup>n-</sup> calculated with the B3LYP functional using a D3BJ def2-TZVP(-f) basis and visualised by IboView.]]

== Consequences on bonding ==
The inversion of ligand fields has interesting implications on the nature of reactivity of organometallic complexes. This [[Chemistry:Sigma non-innocence|sigma non-innocence]] of ligands arising from inverted ligand fields could therefore be used to tune reactivity of complexes and open space in understanding the mechanisms of existing reactions.

In an analysis of the [ZnF<sub>4</sub>]<sup>2-</sup> , it was found that due to ligand field inversion displayed in this species, core ionization removes an electron from the metal-rich bonding t<sub>2</sub> orbital, lengthening the Zn-F bonds. This is contrary to the classical ligand field where ionization would remove an electron from the antibonding t<sub>2</sub> orbital shortening the Zn-F bonds.<ref name=":0" />

The presence of electron-deficient ligands also result in an inverted ligand field. Calculations have shown that the large O 2p contribution into the LUMO/LUMO<sup>+1</sup> in [(L<sup>TEED</sup>Cu)<sub>2</sub>(O<sub>2</sub>)]<sup>2+</sup> should make the complex highly oxidizing as it contains electron deficient O<sup>2-</sup> ligands.<ref name=":4" /> Studies have corroborated this property as this complex has shown to be able to undergo C-H and C-F activation and aromatic hydroxylation.<ref>{{Cite journal |last1=Mirica |first1=Liviu M. |last2=Ottenwaelder |first2=Xavier |last3=Stack |first3=T. Daniel P. |date=2004-05-11 |title=Structure and Spectroscopy of Copper—Dioxygen Complexes |url=http://dx.doi.org/10.1002/chin.200419297 |journal=ChemInform |volume=35 |issue=19 |doi=10.1002/chin.200419297 |issn=0931-7597}}</ref><ref>{{Cite journal |last1=Company |first1=Anna |last2=Palavicini |first2=Sara |last3=Garcia-Bosch |first3=Isaac |last4=Mas-Ballesté |first4=Ruben |last5=Que |first5=Lawrence |last6=Rybak-Akimova |first6=Elena V. |last7=Casella |first7=Luigi |last8=Ribas |first8=Xavi |last9=Costas |first9=Miquel |date=2008-04-18 |title=Tyrosinase-Like Reactivity in a CuIII2(μ-O)2 Species |url=http://dx.doi.org/10.1002/chem.200800229 |journal=Chemistry - A European Journal |volume=14 |issue=12 |pages=3535–3538 |doi=10.1002/chem.200800229 |pmid=18348133 |issn=0947-6539}}</ref><ref>{{Cite journal |last1=Serrano-Plana |first1=Joan |last2=Garcia-Bosch |first2=Isaac |last3=Miyake |first3=Ryosuke |last4=Costas |first4=Miquel |last5=Company |first5=Anna |date=2014-09-01 |title=Selective Ortho -Hydroxylation-Defluorination of 2-Fluorophenolates with a Bis(μ-oxo)dicopper(III) Species |url=https://onlinelibrary.wiley.com/doi/10.1002/anie.201405060 |journal=Angewandte Chemie International Edition |language=en |volume=53 |issue=36 |pages=9608–9612 |doi=10.1002/anie.201405060|pmid=25044926 }}</ref>

There is evidence showing that reductive elimination on species displaying ligand field inversion do not undergo a redox event at the metal center. The C-CF<sub>3</sub> bond formation by "Ni(IV)" complexes<ref>{{Cite journal |last1=Bour |first1=James R. |last2=Camasso |first2=Nicole M. |last3=Sanford |first3=Melanie S. |date=2015-06-16 |title=Oxidation of Ni(II) to Ni(IV) with Aryl Electrophiles Enables Ni-Mediated Aryl–CF<sub>3</sub> Coupling |url=http://dx.doi.org/10.1021/jacs.5b04892 |journal=Journal of the American Chemical Society |volume=137 |issue=25 |pages=8034–8037 |doi=10.1021/jacs.5b04892 |pmid=26079544 |issn=0002-7863}}</ref> was completed without redox participation of the Nickel.<ref name=":7">{{Cite journal |last1=Steen |first1=Jelte S. |last2=Knizia |first2=Gerald |last3=Klein |first3=Johannes E. M. N. |date=2019-07-15 |title=σ‐Noninnocence: Masked Phenyl‐Cation Transfer at Formal Ni(IV) |url=http://dx.doi.org/10.1002/ange.201906658 |journal=Angewandte Chemie |volume=131 |issue=37 |pages=13267–13273 |doi=10.1002/ange.201906658 |s2cid=241689909 |issn=0044-8249}}</ref> The metal appears to remain Ni(II) throughout the reaction. The mechanism is thought to be through the attack of a masked electrophilic cation by anionic CF<sub>3</sub>. The electron deficiency here is due to the inverted ligand field.<ref name=":7" />

== References ==
{{Reflist}}

[[Category:Chemical bonding]]
[[Category:Inorganic chemistry]]
[[Category:Transition metals| ]]

{{Sourceattribution|Inverted ligand field theory}}