View source for Chemistry:Functional analog

In chemistry and pharmacology, '''functional analogs''' are [[Chemistry:Chemical compound|chemical compound]]s that have similar [[Physics:Physical property|physical]], [[Chemistry:Chemical property|chemical]], [[Biology:Biochemistry|biochemical]], or [[Biology:Pharmacology|pharmacological]] properties. Functional analogs are not necessarily [[Chemistry:Structural analog|structural analog]]s with a similar [[Chemistry:Chemical structure|chemical structure]].<ref>{{cite journal|doi=10.1021/jm020155c|pmid=12213076|title=Do Structurally Similar Molecules Have Similar Biological Activity?|journal=Journal of Medicinal Chemistry|volume=45|issue=19|pages=4350–8|year=2002|last1=Martin|first1=Yvonne C.|last2=Kofron|first2=James L.|last3=Traphagen|first3=Linda M.}}</ref>  An example of pharmacological functional analogs are [[Biology:Morphine|morphine]], [[Chemistry:Heroin|heroin]] and [[Chemistry:Fentanyl|fentanyl]], which have the same mechanism of action, but fentanyl is structurally quite different from the other two with significant variance in dosage.<ref name="Mutschler">{{Cite book|last1=Mutschler|first1=Ernst|last2=Schäfer-Korting|first2=Monika|title=Arzneimittelwirkungen|language=German|location=Stuttgart|publisher=Wissenschaftliche Verlagsgesellschaft|year=2001|edition=8|pages=214f, 286|isbn=3-8047-1763-2}}</ref>
<gallery>
File:Morphin - Morphine.svg|[[Biology:Morphine|Morphine]]
File:Heroin - Heroine.svg|[[Chemistry:Heroin|Heroin]]
File:Fentanyl2DCSD.svg|[[Chemistry:Fentanyl|Fentanyl]]
</gallery>

==See also==
*Federal Analogue Act

==References==
{{reflist}}

[[Category:Chemical nomenclature]]
[[Category:Pharmacology]]



{{Sourceattribution|Functional analog (chemistry)|1}}