View source for Biology:TRNA pseudouridine13 synthase

{{Infobox enzyme
| Name       = tRNA pseudouridine<sup>13</sup> synthase
| EC_number  = 5.4.99.27
| CAS_number = 430429-15-5
| GO_code    =
| image      = 
| width      = 
| caption    =  
}}
'''tRNA pseudouridine<sup>13</sup> synthase''' ({{EnzExplorer|5.4.99.27}}, ''TruD'', ''YgbO'', ''tRNA PSI13 synthase'', ''RNA:PSI-synthase Pus7p'', ''Pus7p'', ''RNA:pseudouridine-synthase Pus7p'', ''Pus7 protein'') is an [[Biology:Enzyme|enzyme]] with [[Biology:List of enzymes|systematic name]] ''tRNA-uridine<sup>13</sup> uracil mutase''.<ref>{{cite journal | vauthors = Ericsson UB, Nordlund P, Hallberg BM | title = X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold | journal = FEBS Letters | volume = 565 | issue = 1–3 | pages = 59–64 | date = May 2004 | pmid = 15135053 | doi = 10.1016/j.febslet.2004.03.085 | s2cid = 31602560 }}</ref><ref>{{cite journal | vauthors = Chan CM, Huang RH | title = Enzymatic characterization and mutational studies of TruD--the fifth family of pseudouridine synthases | journal = Archives of Biochemistry and Biophysics | volume = 489 | issue = 1–2 | pages = 15–9 | date = September 2009 | pmid = 19664587 | doi = 10.1016/j.abb.2009.07.023 }}</ref><ref>{{cite journal | vauthors = Kaya Y, Ofengand J | title = A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya | journal = RNA | volume = 9 | issue = 6 | pages = 711–21 | date = June 2003 | pmid = 12756329 | pmc = 1370438 | doi = 10.1261/rna.5230603 }}</ref><ref>{{cite journal | vauthors = Behm-Ansmant I, Urban A, Ma X, Yu YT, Motorin Y, Branlant C | title = The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Psi-synthase also acting on tRNAs | journal = RNA | volume = 9 | issue = 11 | pages = 1371–82 | date = November 2003 | pmid = 14561887 | pmc = 1287059 | doi = 10.1261/rna.5520403 }}</ref><ref>{{cite journal | vauthors = Urban A, Behm-Ansmant I, Branlant C, Motorin Y | title = RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:{Psi}-synthase Pus7p | journal = The Journal of Biological Chemistry | volume = 284 | issue = 9 | pages = 5845–58 | date = February 2009 | pmid = 19114708 | doi = 10.1074/jbc.m807986200 | s2cid = 19586610 | url = https://hal.archives-ouvertes.fr/hal-01738433/file/Urban%20et%20al.%2C%20JBC%2C%202009.pdf | doi-access = free }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]

: tRNA uridine<sup>13</sup> <math>\rightleftharpoons</math> tRNA pseudouridine<sup>13</sup>

Pseudouridine synthase TruD from ''[[Biology:Escherichia coli|Escherichia coli]]'' specifically acts on uridine<sup>13</sup> in tRNA.

== References ==
{{reflist}}

== External links ==
* {{MeshName|TRNA+pseudouridine13+synthase}}

{{Mutases}}
{{Enzymes}}

[[Category:EC 5.4.99]]

{{Sourceattribution|TRNA pseudouridine13 synthase}}