View source for Biology:MEF2B

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Myocyte enhancer binding factor 2B (MEF2B)''' is a transcription factor part of the MEF2 gene family including [[Biology:Myocyte-specific enhancer factor 2A|MEF2A]], [[Biology:MEF2C|MEF2C]], and [[Biology:MEF2D|MEF2D]].<ref>{{Cite journal|last1=Krenács|first1=Dóra|last2=Borbényi|first2=Zita|last3=Bedekovics|first3=Judit|last4=Méhes|first4=Gábor|last5=Bagdi|first5=Enikő|last6=Krenács|first6=László|date=2015-09-01|title=Pattern of MEF2B expression in lymphoid tissues and in malignant lymphomas|journal=Virchows Archiv|volume=467|issue=3|pages=345–355|doi=10.1007/s00428-015-1796-6|issn=1432-2307|pmid=26089142|s2cid=25535467|url=https://publicatio.bibl.u-szeged.hu/27166/1/Krenacs.pdf }}</ref><ref>{{Cite journal|last1=Rodríguez|first1=Andrés I.|last2=Csányi|first2=Gábor|last3=Ranayhossaini|first3=Daniel J.|last4=Feck|first4=Douglas M.|last5=Blose|first5=Kory J.|last6=Assatourian|first6=Lillian|last7=Vorp|first7=David A.|last8=Pagano|first8=Patrick J.|date=2015-02-01|title=MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells|journal=Arteriosclerosis, Thrombosis, and Vascular Biology|volume=35|issue=2|pages=430–438|doi=10.1161/ATVBAHA.114.304936|issn=1524-4636|pmc=4409426|pmid=25550204}}</ref> However, MEF2B is distant from the other three branches of MEF2 genes as it lacks the protein-coding Holliday junction recognition protein C-terminal (HJURP_C) region in vertebrates.<ref name=":0">{{Cite journal|last1=Wu|first1=Wenwu|last2=de Folter|first2=Stefan|last3=Shen|first3=Xia|last4=Zhang|first4=Wenqian|last5=Tao|first5=Shiheng|date=2011-01-01|title=Vertebrate paralogous MEF2 genes: origin, conservation, and evolution|journal=PLOS ONE|volume=6|issue=3|pages=e17334|doi=10.1371/journal.pone.0017334|issn=1932-6203|pmc=3048864|pmid=21394201|bibcode=2011PLoSO...617334W|doi-access=free}}</ref>

== Functions ==
The MEF2 gene family is expressed in muscle-specific gene activation and maintenance during development.<ref name=":0" /><ref>{{Cite journal|last1=Buchberger|first1=A.|last2=Arnold|first2=H. H.|date=1999-06-01|title=The MADS domain containing transcription factor cMef2a is expressed in heart and skeletal muscle during embryonic chick development|journal=Development Genes and Evolution|volume=209|issue=6|pages=376–381|issn=0949-944X|pmid=10370120|doi=10.1007/s004270050267|s2cid=2819535}}</ref> MEF2B mRNA is present in skeletal, smooth, brain and heart muscles.<ref name=":1">{{Cite journal|last1=Katoh|first1=Y.|last2=Molkentin|first2=J. D.|last3=Dave|first3=V.|last4=Olson|first4=E. N.|last5=Periasamy|first5=M.|date=1998-01-16|title=MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression|journal=The Journal of Biological Chemistry|volume=273|issue=3|pages=1511–1518|issn=0021-9258|pmid=9430690|doi=10.1074/jbc.273.3.1511|doi-access=free}}</ref> MEF2B is directly involved in smooth muscle myosin heavy chain (SMHC) gene regulation. Overexpression of MEF2B will activate the SMHC promoter in smooth muscle when it is bound to the A/T-rich element of the promoter.<ref name=":1" />

== Interactions ==

MEF2B has been shown to interact with [[Biology:CABIN1|CABIN1]].<ref name=pmid12700764>{{cite journal | vauthors = Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L | title = Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2 | journal = Nature | volume = 422 | issue = 6933 | pages = 730–4 | date = Apr 2003 | pmid = 12700764 | doi = 10.1038/nature01555 | bibcode = 2003Natur.422..730H | s2cid = 4430658 }}</ref><ref name=pmid10531067>{{cite journal | vauthors = Youn HD, Sun L, Prywes R, Liu JO | title = Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2 | journal = Science | volume = 286 | issue = 5440 | pages = 790–3 | date = Oct 1999 | pmid = 10531067 | doi = 10.1126/science.286.5440.790 }}</ref>

== Clinical relevance ==

Recurrent mutations in this gene have been associated with cases of diffuse large B-cell lymphoma.<ref name="MorinMendez-Lago2011">{{cite journal | vauthors = Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA | display-authors = 6 | title = Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma | journal = Nature | volume = 476 | issue = 7360 | pages = 298–303 | date = Aug 2011 | pmid = 21796119 | pmc = 3210554 | doi = 10.1038/nature10351 | bibcode = 2011Natur.476..298M | url = https://researchonline.jcu.edu.au/43192/6/43192_Morin%20et%20al_2011.pdf }}</ref> In its mutated form, MEF2B can lead to deregulation of the proto-oncogene BCL6 expression in diffuse large B-cell lymphomas (DLBCL).<ref name=":2">{{Cite journal|last1=Ying|first1=Carol Y.|last2=Dominguez-Sola|first2=David|last3=Fabi|first3=Melissa|last4=Lorenz|first4=Ivo C.|last5=Hussein|first5=Shafinaz|last6=Bansal|first6=Mukesh|last7=Califano|first7=Andrea|last8=Pasqualucci|first8=Laura|last9=Basso|first9=Katia|date=2013-10-01|title=MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma|journal=Nature Immunology|volume=14|issue=10|pages=1084–1092|doi=10.1038/ni.2688|issn=1529-2916|pmc=3954820|pmid=23974956}}</ref> Mutations of MEF2B enhance its transcriptional activity due to either a disruption with its corepressor CABIN1 or causing the gene to become insensitive to inhibitory signaling events.<ref name=":2" />

== See also ==
* [[Biology:Mef2|Mef2]]

== References ==
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== Further reading ==
{{refbegin|33em}}
* {{cite journal | vauthors = Yu YT, Breitbart RE, Smoot LB, Lee Y, Mahdavi V, Nadal-Ginard B | title = Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors | journal = Genes & Development | volume = 6 | issue = 9 | pages = 1783–98 | date = Sep 1992 | pmid = 1516833 | doi = 10.1101/gad.6.9.1783 | doi-access = free }}
* {{cite journal | vauthors = Pollock R, Treisman R | title = Human SRF-related proteins: DNA-binding properties and potential regulatory targets | journal = Genes & Development | volume = 5 | issue = 12A | pages = 2327–41 | date = Dec 1991 | pmid = 1748287 | doi = 10.1101/gad.5.12a.2327 | doi-access = free }}
* {{cite journal | vauthors = Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL | title = Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23 | journal = Genomics | volume = 29 | issue = 3 | pages = 704–11 | date = Oct 1995 | pmid = 8575763 | doi = 10.1006/geno.1995.9007 }}
* {{cite journal | vauthors = Katoh Y, Molkentin JD, Dave V, Olson EN, Periasamy M | title = MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression | journal = The Journal of Biological Chemistry | volume = 273 | issue = 3 | pages = 1511–8 | date = Jan 1998 | pmid = 9430690 | doi = 10.1074/jbc.273.3.1511 | doi-access = free }}
* {{cite journal | vauthors = Iida K, Hidaka K, Takeuchi M, Nakayama M, Yutani C, Mukai T, Morisaki T | title = Expression of MEF2 genes during human cardiac development | journal = The Tohoku Journal of Experimental Medicine | volume = 187 | issue = 1 | pages = 15–23 | date = Jan 1999 | pmid = 10458488 | doi = 10.1620/tjem.187.15 | doi-access = free }}
* {{cite journal | vauthors = Youn HD, Sun L, Prywes R, Liu JO | title = Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2 | journal = Science | volume = 286 | issue = 5440 | pages = 790–3 | date = Oct 1999 | pmid = 10531067 | doi = 10.1126/science.286.5440.790 }}
* {{cite journal | vauthors = Li M, Linseman DA, Allen MP, Meintzer MK, Wang X, Laessig T, Wierman ME, Heidenreich KA | title = Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons | journal = The Journal of Neuroscience | volume = 21 | issue = 17 | pages = 6544–52 | date = Sep 2001 | pmid = 11517243 | doi =  10.1523/JNEUROSCI.21-17-06544.2001| pmc = 6763101 }}
* {{cite journal | vauthors = Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L | title = Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2 | journal = Nature | volume = 422 | issue = 6933 | pages = 730–4 | date = Apr 2003 | pmid = 12700764 | doi = 10.1038/nature01555 | bibcode = 2003Natur.422..730H | s2cid = 4430658 }}
* {{cite journal | vauthors = Konig S, Hinard V, Arnaudeau S, Holzer N, Potter G, Bader CR, Bernheim L | title = Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 27 | pages = 28187–96 | date = Jul 2004 | pmid = 15084602 | doi = 10.1074/jbc.M313932200 | doi-access = free }}
* {{cite journal | vauthors = Han A, He J, Wu Y, Liu JO, Chen L | title = Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2 | journal = Journal of Molecular Biology | volume = 345 | issue = 1 | pages = 91–102 | date = Jan 2005 | pmid = 15567413 | doi = 10.1016/j.jmb.2004.10.033 }}
* {{cite journal | vauthors = Gong X, Tsai SW, Yan B, Rubin LP | title = Cooperation between MEF2 and PPARgamma in human intestinal beta,beta-carotene 15,15'-monooxygenase gene expression | journal = BMC Molecular Biology | volume = 7 | pages = 7 | year = 2006 | pmid = 16504037 | pmc = 1526748 | doi = 10.1186/1471-2199-7-7 | doi-access = free }}
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== External links ==
* {{MeshName|MEF2B+protein,+human}}

{{PDB Gallery|geneid=4207}}
{{Transcription factors|g4}}

[[Category:Transcription factors]]



{{Sourceattribution|MEF2B}}