View source for Biology:LIM domain-binding protein family

{{short description|Family of proteins}}
{{Infobox protein family
| Symbol = LIM_bind
| Name = LIM-domain binding protein
| image = 
| width = 
| caption = 
| Pfam = PF01803
| Pfam_clan =  
| InterPro = IPR002691
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 1j2o
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = 
| CDD = 
}}
In molecular biology, the '''LIM domain-binding protein family''' is a [[Biology:Protein family|family of proteins]] which [[Physics:Molecular binding|bind]]s to the [[Biology:LIM domain|LIM domain]] of LIM (LIN-11, Isl-1 and MEC-3) homeodomain proteins which are transcriptional regulators of development.

==Examples==
Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of [[Biology:Neuron|neuronal cells]] during development, it is co-expressed with [[Biology:ISL1|ISL1]] in early motor neuron differentiation and has a suggested role in the ISL1 dependent development of motor neurons.<ref name="pmid8876198">{{cite journal |vauthors=Jurata LW, Kenny DA, Gill GN | title = Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 21 | pages = 11693–8 |date=October 1996 | pmid = 8876198 | pmc = 38120 | doi = 10.1073/pnas.93.21.11693| bibcode = 1996PNAS...9311693J | doi-access = free }}</ref> It is suggested that these [[Biology:Protein|protein]]s act [[Biology:Synergy|synergistically]] to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class [[Biology:Transcription factor|transcription factor]]s both of which have essential roles in development.<ref name="pmid9192866">{{cite journal |vauthors=Bach I, Carriere C, Ostendorff HP, Andersen B, Rosenfeld MG | title = A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins | journal = Genes Dev. | volume = 11 | issue = 11 | pages = 1370–80 |date=June 1997 | pmid = 9192866 | doi = 10.1101/gad.11.11.1370| doi-access = free }}</ref> The ''[[Biology:Drosophila melanogaster|Drosophila melanogaster]]'' protein Chip is required for segmentation and activity of a remote [[Physics:Wing|wing]] margin enhancer.<ref name="pmid9334334">{{cite journal |vauthors=Morcillo P, Rosen C, Baylies MK, Dorsett D | title = Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila | journal = Genes Dev. | volume = 11 | issue = 20 | pages = 2729–40 |date=October 1997 | pmid = 9334334 | pmc = 316608 | doi = 10.1101/gad.11.20.2729}}</ref> Chip is a ubiquitous [[Biology:Chromosome|chromosomal]] factor required for normal [[Biology:Gene expression|expression]] of diverse genes at many stages of development.<ref name="pmid9334334"/> It is suggested that Chip cooperates with different LIM domain [[Biology:Proteins|proteins]] and other factors to structurally support remote enhancer-promoter interactions.<ref name="pmid9334334"/>

==References==
{{reflist}}
{{InterPro content|IPR002691}}

[[Category:Protein families]]

{{Sourceattribution|LIM domain-binding protein family}}